Protein Details: Glutamate receptor 3

Protein ID

ICDB_Pro_1736

Protein Name

Glutamate receptor 3

Gene Name

Gria3; GluA3; Glur3; Kiaa4184

Organism

Mus musculus (Mouse)

Length

888 amino acids

AlphaFoldDB

AF-Q9Z2W9-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a ligand-gated cation channel; gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA); quisqualic acid; and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change; leading to the opening of the cation channel; and thereby converts the chemical signal to an electrical impulse upon entry of calcium (By similarity). The receptor then desensitizes rapidly and enters a transient inactive state; characterized by the presence of bound agonist. In the presence of CACNG8; shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).

Sequence

MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI

PDB Structures

3LSW 3LSX

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 502; /ligand="L-glutamate" BINDING 504; /ligand="L-glutamate" BINDING 509; /ligand="L-glutamate" BINDING 680; /ligand="L-glutamate" BINDING 681; /ligand="L-glutamate" BINDING 731; /ligand="L-glutamate"

Disease

Location

DOI ID

10.1007/s00335-001-1001-x; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1016/j.neuron.2005.06.035; 10.1021/pr0701254; 10.1016/j.cell.2010.12.001; 10.1016/j.neuron.2016.11.046; 10.1038/s41586-021-03540-0; 10.1021/jm901905j

RefSeq

NP_001268858.1 [Q9Z2W9-1]; NP_058582.3 [Q9Z2W9-1]; XP_006541583.1; XP_017174034.1 [Q9Z2W9-1];